If you've scrolled TikTok or skincare Instagram lately, you've probably heard about "salmon DNA" serum. Here's a simple, no-hype guide to what PDRN is, why it's everywhere right now, and how to fit it into a routine for skin after 40.
What is PDRN?
PDRN (polydeoxyribonucleotide) is an ingredient made from purified salmon DNA fragments. It became popular in Korean skincare and is now one of the most talked-about ingredients of the year. In skincare, it's used to help skin look smoother, bouncier and more refreshed.
Why people over 40 are interested
After 40, many of us notice skin feels drier and looks less plump than it used to. Lightweight serums with PDRN are popular because they add hydration and a fresh, healthy-looking glow without feeling heavy.
PDRN + copper peptides: a popular pairing
Copper peptides (GHK-Cu) are another ingredient getting a lot of attention for helping skin look firmer and more even. Our Copper Peptide + PDRN Serum ($17.99) combines both, plus niacinamide, vitamin C and hyaluronic acid, in a fragrance-free formula.
How to use it (the easy way)
- Cleanse and pat skin dry.
- Smooth 2–3 drops over face and neck.
- Follow with a moisturizer to lock in hydration. For dry skin, try a richer cream such as our Rich Face Cream for Extremely Dry Skin.
- In the morning, finish with sunscreen.
Start with once a day, and always patch test a new product first.
The bottom line
PDRN is a trend worth trying if you like light, hydrating serums. Keep your routine simple and consistent: cleanser, serum, moisturizer, and sunscreen in the morning.
Not sure if PDRN fits your routine? Take the free 60-second skin quiz → and get a simple routine matched to your skin after 40.
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